|
KMID : 0617320030120010238
|
|
Journal of Pharmacetical Sceiences Ewha Womans University
2003 Volume.12 No. 1 p.238 ~ p.241
|
|
|
Design, Synthesis and Binding Affinity of 3´-Fluoro Analogues of Cl-IB-MECA as Adenosine A₃ Receptor Ligands
|
|
Lim, Moo Hong
Kim, Hea Ok/Moon, Hyung Ryoung/Lee, Seung Jin/Chun, Moon Woo/Gao, Zhan-Guo/Melman, Neli
|
|
|
Abstract
|
|
|
|
Several 3´-fluoro analogues, la, lb, and lc of selective and potent adenosine A₃ receptor agonist, Cl-IB-MECA were synthesized from D-xylose via highly regioselective opening of lyxo-epoxides, 8a and 8b with fluoride anion. Compared to the high binding affinity of CI-IB-MECA to the A₃ adenosine receptor, the corresponding 3´-fluoro derivative showed remarkably decreased binding affinity, indicating that 3´-hydroxyl group acts as hydrogen bonding acceptor, not hydrogen bonding donor like fluorineatom in binding to the A₃ adenosine receptor.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|